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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Chai M, Jiang M, Vergnes L, Fu X, de Barros SC, Doan NB, Huang W, Chu J, Jiao J, Herschman H, et al

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Progressive Dosing Protocols Rather than maintaining a static dose throughout a research cycle, progressive protocols involve systematic dose adjustments: Weeks 1-2 : Start at 15mg daily to assess baseline tolerance and response Weeks 3-4 : Increase to 25mg daily if well-tolerated Weeks 5-8 : Potentially increase to 30-35mg based on goals and response Weeks 9-12 : Maintain optimal dose identified during earlier weeks This approach allows for individualized optimization while maintaining safety margins

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This can cause severe illness and does not make up for the lost time

Neoplastic and preneoplastic lesions induced in female C3H mice by diets containing diethylstilbestrol or 17 beta-estradiol