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up-regulating brain-derived neurotrophic factor [BDNF], nerve growth factor [NGF], neurotrophin [NT]-3 and NT-4/5 expression, etc.), attenuating blood-brain barrier (BBB) disruption, improving mitochondrial function, maintaining calcium ion homeostasis (e.g

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This matches research showing NAD+ therapy helps clear brain fog by reviving brain cells and balancing neurotransmitters [9]

Additional harmful metabolites produced by dysbiotic microbiota, such as p-cresol sulfate, further impair BBB integrity by activating signaling pathways that degrade tight junction proteins [259]

doi: 10.1056/NEJMoa1812389 10 NealBPerkovicVMahaffeyKWde ZeeuwDFulcherGEronduNet al

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