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Pharmacokinetics and Pharmacodynamics (PK/PD) : Assessing exposure over time, half-life, exposureresponse relationships, and alignment of PK properties when studied together

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Using Cre/loxP technology, we have generated a novel genetic mouse model that allows for the reactivation of endogenous Gcg with tissue specificity

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Muscle cramps are an independent risk factor for diminished health-related quality of life

These studies indicate the potential of utilizing the de novo pathway, a less extensively studied pathway, as a therapeutic strategy for metabolic diseases Barth syndrome is a rare disease caused by mutations in the tafazzin gene encoding for cardiolipin (CL), a phospholipid specific for the mitochondria 303