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Clinical trials measure what happens when patients stop a medication and receive no alternative

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Behind this phenomenon is the deep intervention of GLP-1 in the "central plan" of cellular energy metabolism: it activates GLP-1 receptors, reprograms cellular energy distribution pathways, and shifts the body from an "energy wasting" metabolic mode to an "efficient and economical" one, thereby achieving the dual goals of disease treatment and health improvement

This might include eating on a schedule rather than waiting for hunger cues, since GLP-1 therapy specifically blunts those cues