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Supplementary Information Acknowledgement The authors would like to thank the UK Biobank for approving our application (#42468)

Lower Risk Across Multiple Substances Compared with people using other diabetes medications, patients taking GLP-1 drugs had a 14% lower risk of developing any substance use disorder

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8E) that ORI@CPD-Lipo (DiR-labeled) was most distributed in the liver and spleen, and low levels distributed in other organs (Fig

Mounjaro (tirzepatide) commonly begins at 2.5 mg once per week