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The most important consideration is consistency

Nitrosative stress leads to the overproduction of RNS, including nitric oxide (NO) which triggers an immune response, and its derivatives: nitrous acid (HNO 2 ), nitrogen dioxide (NO 2 ), and nitric acid (HNO 3 ) (91)

It serves as the cofactor for several antioxidant enzymes

This displaced material may press against nearby nerve roots, causing the characteristic pain, numbness, and weakness associated with disc problems

Holick, New England Journal of Medicine , 2007)

This is why, for example, short-acting benzodiazepines such as alprazolam and lorazepam are more difficult to discontinue than long-acting benzodiazepines such as diazepam and clonazepam