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This was revealed through analysis using the Broad Institute's Connectivity Map, a database of gene expression responses to known compounds

This mechanism of action explains why these medications often affect digestion as well

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276 While AD has genetic causes, notably the apolipoprotein E4 (ApoE4) allele, which promotes the accumulation of A plaques through the MAPK signaling pathway, 277 the majority of cases are sporadic and strongly age-associated

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