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Mercks medicinal-chemistry effort produced a series of peptidomimetics small molecules that mimic what those peptides do at the receptor while surviving oral administration

Garlic-derived compounds may also inhibit other enzymes in this pathway, including sterol 4-methyl oxidase (41)

Lee et al., 2004a,b

The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens

KOA is characterized by articular cartilage injury, accompanied by synovitis and subchondral bone sclerosis [5]

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