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Importante destacar que existe un circuito disociado en el tronco enceflico entre saciedad y aversin: mientras la activacin del NTS induce prdida de apetito sin efectos adversos, la del rea postrema puede generar nuseas, explicando los efectos secundarios gastrointestinales que presentan hasta un 40% de los pacientes con GLP-1RA
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Nrf2 induces malignant transformation of hepatic progenitor cells by inducing -catenin expression
While no clinical trials have firmly established its efficacy or safety in humans, the volume of in-vitro and animal model data provides a compelling rationale for its continued investigation