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This is particularly important for drugs with narrow therapeutic window or potential for resistance development such as antibiotics and cytotoxic drugs (Bardelmeijer et al

FOXO4-DRI enters senescent cells and competitively binds to p53 through its modified peptide sequence, displacing endogenous FOXO4 and freeing p53 to activate cell death pathways including BAX and PUMA

Rotating sites systematically helps prevent accumulation of local reactions

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While the provided dosage ranges may serve as guidelines for in vitro studies, it is important to note that future research findings, may lead to adjustments in these recommendations

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