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Surface functionalization of PLGA nanoparticles to increase transport across the BBB for Alzheimers disease
Neely et al., 2017)
The microglial branch KYN 3-monooxygenase (KMO) metabolizes KYN into 3-hydroxykynurenine (3-HK), which can then follow two main metabolic routes: conversion into 3-hydroxyanthranilic acid (3-HAA) via kynureninase or transformation into xanthurenic acid through KAT
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Lei Yuan, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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