Aquatide activation of SIRT1 reduces cellular senescence through a SIRT1-FOXO1-autophagy axis
The researchers noted that compared with the control group, the epithalamin-treated patients exhibited [10]: Decelerated aging of the cardiovascular system Decreased rate of cardiovascular mortality and cardiovascular failure (-50%) Less age-associated impairment of physical endurance Normalized circadian rhythm for melatonin production Normalized circadian rhythm for lipid (fats) and carbohydrate metabolism Lower rate of mortality (-28%) The follow-up study on long-term epithalamin treatment represents strong evidence of eptithalons favorable safety profile and relative absence of notable epithalon side effects
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Fabrini R, Bocedi A, Del Grosso E, Morici L, Federici G, Palleschi A et al
Cells untreated (DMEM) or treated with solvent only (DMSO) did not show significant differences for the various parameters analyzed (Figure 2B)
Given the detrimental effects of such hepatotoxic agents, there is an increasing interest in natural antioxidants in foods high in non-enzymatic antioxidants including Vitamin C, and E, Carotenoids, Flavonoids, and polyphenols that can provide protective effects against liver damage (4)