In 2021, a concerning trend was noted in an analysis of more than 20,000 poisoning exposures to marijuana edibles that were reported nationally
In the brain, GLP-1 signaling in the hypothalamus, hippocampus, and brain stem mediates neuroprotective mechanisms that reduce neuroinflammation, enhance brain cell survival, suppress the accumulation of amyloid/tau protein, and modulate appetite
Symptoms include shakiness, sweating, confusion, or rapid heartbeat
Some patients benefit from GLP-1 dominant therapy (semaglutide, starting at $189/mo), while others respond better to dual-receptor compounds like GLP-Squared Injection (at $289/mo month-to-month, or from $249/mo on the 3-month plan)
As shown in Fig
Handa M, Sanap SN, Bhatta RS et al (2023) Simultaneous intranasal codelivery of donepezil and memantine in a nanocolloidal carrier: optimization, pharmacokinetics, and pharmacodynamics studies