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As individuals age, there is an increase in pathogenic and putrefactive bacteria (e.g., Proteus ), while helpful bacteria such as Lactobacillus and Bifidobacterium diminish

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Hypoxic conditions elevated the inflammation in steatotic hepatocytes and increased the release of EVs derived from fat-laden hepatocytes, which stimulate the activation of hepatic stellate cells and the inflammatory phenotype in Kupffer cells [111, 112]