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Mammalian cell culture, transfection and generation of stable cell lines Mammalian cell cultures were performed following previously published protocols 6

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1.1 Diagnostic challenges and the need for an integrative genomic framework Neurodegenerative disordersincluding Alzheimers disease (AD), Parkinsons disease, frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), among othersrepresent one of the most pressing challenges for modern medicine