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Lixisenatide is structurally related to exendin-4 (six lysine residues have been added to the C terminus, and one proline in the C-terminal region has been deleted) but can be administered once daily (QD)
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This tripeptide, composed of three amino acidscysteine, glutamic acid, and glycineplays a fundamental role in protecting cells from oxidative stress and supporting the body's natural detoxification processes
The model is then combined with a comprehensive glutathione metabolism model, facilitating the simulation of quinone redox cycling, and adduct-induced GSH depletion
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Cellular signalling research
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