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This information is critical for understanding the clinical implications of molecular design and for guiding the rational use of GLP-1RAs across diverse therapeutic contexts

3.1% with placebo) in people with obesity without diabetes, the highest reported among approved obesity pharmacotherapies [27]

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This randomized, double-blind, placebo-controlled study enrolled 338 adults with obesity (BMI 30 kg/m) or overweight with at least one weight-related comorbidity (BMI 27 kg/m)