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Food-related neural circuitry in Prader-Willi syndrome: response to high-versus low-calorie foods

Truncation studies showed that the membrane proximal 61 amino acids of GP130 are sufficient for signal transduction (68), and later it was shown for GHR that the membrane proximal 20 residues (which includes the Box1 motif) of the ICD is sufficient for JAK2 binding, but not sufficient for GH-induced activation of JAK2 (69)

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At one point, she feared she would die from the excruciating pain from the medication often called a miracle drug for its weight-shedding properties, despite being created to treat type-2 diabetes

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This finding is particularly significant given that some trials extended to 24 weeks of continuous exposure and included individuals with obesity-related health conditions who might have higher baseline health risks