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The SUSTAIN-7 trial and real-world data indicate that women lose an average of 24 pounds per month during months 16, with cumulative 12-month weight loss ranging from 1522% of baseline body weight depending on adherence and lifestyle factors

Eli Lilly has not publicly announced pediatric clinical trials for orforglipron as of early 2026, but the commercial and clinical logic for eventual pediatric development is strong

[DOI] [PubMed] [Google Scholar] 128.Rodeo S.A., Izawa K

Improved insulin sensitivity: A 2022 trial found 500 mg daily for 6 months lowered HbA1c in elderly diabetics

8 and (2) whilst controversial, 19 it can be argued that the relatively small number of patients in the trial required to demonstrate the outcome is testament to the strength of the effect

de la Rosa, L