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1961 obese, non-diabetic participants lost approximately 15% of their body weight over 68 weeks with once-weekly 2.4 mg injectable Semaglutide, alongside lifestyle changes

May help reduce cravings

GLP-1 receptor activation slows gastric emptying and alters gut signaling

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Sanyal Sanyal and colleagues conducted a randomized, double-blind, phase 2 study of retatrutide, a novel triple agonist of GIP, GLP-1 and glucagon receptors, vs

FDA approval is projected between late 2026 and early 2027