LCA is the most potent natural TGR5 agonist among the BAs pool which contains muricholic acid (MCA), hyocholic acid (HCA), ursodeoxycholic acid (UDCA), CA, CDCA, DCA, LCA, and so on (Fig
It also plays an important role in supporting fat metabolism
For instance, myosteatosis impairs muscle health through both metabolic dysfunction and inflammation, while chronic low-grade inflammation negatively affects metabolic balance by inhibiting protein synthesis and increasing proteolysis via signaling pathways [39]
Lactic acidosis is a disease that can cause abdominal and respiratory stress
* N represents the number of participants that finished the treatment in the clinical trial and had a blood draw for the biomarkers under study
Adicionalmente, induce un efecto muy favorable sobre la prevencin de diabetes en personas con prediabetes (HR: 0,07 respecto a placebo)41 (tabla 1)