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1997 Apr;19(3):201-10

The only evidence is experimental: your research outcomes stop aligning with published data, or dose-response curves flatten unexpectedly

DOI: 10.1113/jphysiol.1934.sp003147 Gericke A et al (2011): Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

Figure 2 3.1 Study characteristics and quality The nine publications evaluated included six clinical studies, two case series, and one survey

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In both studies, no serious TEAEs, TEAEs leading to study withdrawal or deaths were reported