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Originally characterized at the University of Florida by the Stephen ORahilly and Robert Kraft groups, the compound has been studied in preclinical research for body composition, adipose tissue lipolysis, glucose homeostasis, skeletal muscle aging, and metabolic disease endpoints

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Prolonged or severe nerve compression can lead to permanent damage including weakness, numbness, or loss of reflexes

Vitamin B12 may counteract some effects of ovarian aging

Peptide degradation follows first-order kinetics, meaning each hour at elevated temperature compounds previous damage

Dennis et al., 2002, 2004