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As OCTN3 mediates sodium-independent carnitine transport and humans lack a functional ortholog of this protein, caution is warranted when extrapolating data on renal carnitine handling from rodent models to humans [78, 79]

Drug-induced liver injury (DILI) is a leading cause of acute liver failure and can be life-threatening

2.5 Combination therapy inhibits the growth of Th- MYCN mouse NB spheroids To assess the antitumor potential of the dual and triple drug combinations in a more physiological model than cell lines, we used a 3D spheroid model of a transgenic mouse that overexpresses MYCN under the control of the tyrosine hydroxylase (Th) promoter

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When tentatively treating individuals with alcohol use disorder using GLP-1R agonists, it is important to take into account the potential aversive effects