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Pathways involved, expressions of endoplasmic reticulum (ER) stress apoptosis marker CHOP , angiogenic markers VEGF-A and its receptor VEGFR1 , and endothelial NO synthase ( eNOS ) were all analyzed by Western blot

86 Notch signaling pathway Notch signaling, intimately involved in embryonic development and maintenance of multicellular organisms in adults, is activated by ligand-receptor interaction between adjacent cells, which leads to successive proteolytic cleavages and releases the notch intracellular domain (NICD)

The ethanolic seed extract produced immunosuppressive and anti-inflammatory effects by inhibiting leukocytes and splenocytes (15) as well as histamine release from mast cells (16)