Glutaminase, which hydrolyzes Gln to glutamate, is a key enzyme in Gln metabolism
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In PIONEER 5, all eligible patients had moderate renal impairment, and overall, renal function was unchanged during the trial period in both groups once the median eGFR ratios (week 31 follow-up relative to baseline) were similar in both groups [HR 1.02, 95% CI 0.271.96 (oral semaglutide)
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It is becoming more common as additional treatments become available but it should always be GP-guided