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In an announcement published on 21 May 2026, Eli Lilly shared the results of the TRIUMPH-1 study, which involved 2,339 participants who were randomised to receive either retatrutide 4mg, 9mg, 12mg (building up every four weeks from 2mg), or placebo

The trial involved 48 participants who randomly received semaglutide or a placebo

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What Retatrutide's Approval Would Mean for Metabolic Healthspan The framing of retatrutide as merely a "more powerful weight-loss drug" undersells its significance to anyone thinking seriously about longevity

PMID: 20121616 Bures J, Cyrany J, Kohoutova D, Frstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M

224 Lipid-derived PPAR ligands PPARs are involved in modulating multiple biological processes, including glucose and lipid metabolism, the inflammatory response, and cell proliferation