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Mounjaro Mechanism of Action: The Full GIP + GLP-1 Dual-Agonist Pathway At a glance Drug class / GIP + GLP-1 dual receptor agonist (twincretin) Molecular weight / approximately 4,813 Da fatty-acid conjugated peptide Primary receptor targets / GIPR and GLP-1R (distinct G-protein coupled receptors) FDA approval date / May 13, 2022 (type 2 diabetes)