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10.1002/hep.29496 Hepatology 12 BozkayaG.KorhanP.CokakliM.ErdalE.SagolO.KarademirS.et al (2012)

Why Individual Weight Loss Results Vary Significantly Two patients on identical semaglutide doses may experience different weight loss outcomes because genetics, metabolism, and appetite regulation vary from person to person

Ca 2+ is not metabolized and an overload of mitochondrial Ca 2+ may break down the electrochemical proton gradient resulting in a deficit of ATP followed by necrosis [89]

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The medication works through well-characterized signaling pathways, and adverse events are documented in extensive safety databases