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A systematic review of the antidepressant effects of glucagon-like peptide 1 ( GLP-1 ) functional agonists: Further link between metabolism and psychopathology Special Section on Translational and Neuroscience Studies in Affective Disorders

Real-world evidence has also emerged regarding dual GLP-1/GIP agonists

Some genetic profiles indicate faster GLP-1 metabolism, necessitating higher maintenance doses

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there is also data to suggest that slower titration regimens (employed in GLP-1-insulin combo therapies), may reduce rates of nausea and vomiting further