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JAMA 325(14):14141425 Garvey WT, Batterham RL, Bhatta M et al (2022) Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial

As appetite shrinks, it is easy to undershoot daily protein targets, which can slow muscle maintenance and metabolism

The second choice of therapy is with non-psychostimulants such as atomoxetine (ATX), which is a selective norepinephrine reuptake inhibitor, guanfacine, and clonidine, which are selective -2 adrenergic receptor agonists [18,19]

In terms of superiority, results of the repeated measures analyses were in general comparable to those of the ANCOVA analyses