This study, which recruited 247 patients, showed that pioglitazone caused significant reductions in steatosis, inflammation, hepatocellular ballooning and improvement in insulin resistance and liver-enzyme levels, despite failing to achieve the primary outcome of improvement in standardized scoring of liver biopsies
DISCUSSION In this study, 7.5 mg of tirzepatide did not produce significant improvements in glycemic control or body weight after switching from 1.0 mg of semaglutide, while the 10 mg dose resulted in significant HbA1c reduction, but not significant weight loss
10.1016/j.obpill.2024.100127 [DOI] [PMC free article] [PubMed] [Google Scholar] 3.Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions
NF-kappa B activation as a pathological mechanism of septic shock and inflammation
Synergy of Dual Engagement Preclinical research suggests that simultaneous GIPR and GLP-1R activation produces metabolic effects that exceed the sum of either pathway alone a finding that has driven sustained interest in dual-agonist research compounds
Neurology 81 , 15311537 (2013)
