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doi: 10.1056/NEJMra2026131 77 FakhrolmobasheriM.Mazaheri-TehraniS.KieliszekM.ZeinalianM.AbbasiM.KarimiF.et al
As in the vector host, in infected macrophages also, inducible NADPH oxidase (NOX2) produces O 2 that can be transformed spontaneously or enzymatically by superoxide dismutases (SODs) to H 2 O 2 , and the latter is dismutated by GPx and catalase (Figure 1B) (Gupta et al., 2011)
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In addition, PAC has the capacity to reduce fever and pain as well as NSAIDs (Messika et al., 2014), and may equally mask the symptoms delaying the objective grading of the disease, but it lacks the NSAIDs anti-inflammatory and antiplatelet activities that might be fundamental in containing COVID-19 exacerbation ( The routinary use of PAC in at risk categories, along with their intrinsically frail conditions, may have further worsen the scarcity of GSH, especially in western countries where PAC consumption is particularly high
10.1038/s41556-018-0184-2PMID: 29941933
