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Experimental Biology and Medicine

Therapeutic regime for SJS/TEN includes discontinuation of allergenic drugs, glucocorticoids, nutrition support, insulin, and intravenous immunoglobulin (IVIG) [24]

In multiple in vitro and animal models, arginine is metabolized by iNOS to generate nitric oxide (NO), thereby enhancing pro-inflammatory responses, whereas its metabolism by Arg1 produces ornithine and polyamines that support tissue repair (3033)

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The lack of standard diagnostic criteria for HT makes the diagnosis process subjective and does not cover the entire spectrum of the disease

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