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Assays, biomarkers, and phenotypic endpoints Biochemical and transcriptional readouts ERR target-gene panels spanning fatty-acid uptake/-oxidation (Cpt1b, Acadl/Acadm), OXPHOS (Ndufs, Uqcrc, Cox), TCA (Cs, Idh), and mitochondrial biogenesis (Ppargc1a, Tfam) provide proximal pharmacodynamic evidence of receptor engagement

Adluri, R

of this final rule with comment period and adds the Emergency Care Access & Timeliness eCQM as discussed in section XVI.B.1

65 The growth factor binding properties of native sulfated GAGs can be integrated into synthetic scaffold matrices through functionalization with specific chemical groups

LT targets the dermis and superficial fascia skin layers, attracting fluid and creating space in the dermis area