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Notably, there was a decrease in the cumulative incidence of severe albuminuria in individuals diagnosed with type 1 diabetes in the 1980s compared with those diagnosed in the 1970s in Finland, although no further improvement was apparent in the 19901999 diagnosis cohort [4]

The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018