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L-DOPA treatment from the viewpoint of neuroprotection
Therefore, the hyperkinetic and hyperdopaminergic states observed in the SPRDtgHD rat model and Trkb Penk -KO mice closely resemble the phenotype of patients with HD
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Moreover, the hydroxyl radical and singlet oxygen disrupt the functions of deoxyribonucleic acid (DNA)-protein crosslinking, distorting the DNA restoration mechanism [8]
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