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Increasing the ratio of AMP to ATP, either by decreasing ATP levels or by increasing exogenous AMP levels, can contribute to cell growth arrest and senescence characteristics [95]

Based on the outcomes of these in vitro studies, a diet containing relatively higher amounts of His, Lys and Thr and relatively lower amounts of Leu, Ile, and Val was developed for preclinical ASD studies (93)

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This mechanism operates through metabolic pathways independent of the incretin system

Short chain fatty acids Short-chain fatty acids (SCFAs) are a major group of metabolites produced by intestinal microorganisms