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PIONEER trial programme has showed around 70% of subjects had achieved their glycaemic target of HbA1c 9%.[23] Another post hoc analysis of PIONEER trials showed Asians were more respondent to semaglutide in terms of HbA1c reduction and weight reduction.[24] It is worth mentioning that in PIONEER 8 trial, most of the Asians (66) were Indians (51).[22] EARLY STAGE OF DIABETES PIONEER 1 has established the clinical efficacy of oral semaglutide as monotherapy and first-line drug after diet and exercise

It is a well-established mechanism for unintended pregnancy in women on oral contraceptives, and semaglutides GI side effect profile creates exactly the conditions where it happens repeatedly during the months of active titration

By improving the health of the brain's vasculature and reducing inflammatory responses, GLP-1R agonists may help preserve cognitive function in individuals with metabolic disorders or neurodegenerative conditions

10.1093/toxsci/kfaa054 54 Health Canada (2021)

Iqbal T, et al