2019 May 9;2019:5028181
Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes mellitus (LEAD-4 Met + TZD)
doi: 10.1111/j.1365-2133.1990.tb06266.x
4.1 Central nervous system effects GLP-1R is distributed throughout various regions in the brain, with the highest concentrations being found in the hippocampus and cerebral cortex, areas mainly responsible for cognitive function, memory improvement, and learning (22), as well as in microglia and astrocytes (23)
Gastrointestinal Burden GLP-1 receptor agonists slow gastric emptying and directly act on the GI tract which is why nausea, vomiting, constipation, and diarrhoea are among the most commonly reported side effects, especially during dose escalation
Continuous variables are presented as mean standard deviation or median (interquartile range) based on distribution, while categorical variables are expressed as frequencies (percentages)