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Patients with GAMT deficiencies have high concentrations of GAA in body fluids and manifest with refractory epilepsy and severe movement disorders

Apart from As stress, induction of different classes of GSTs have been observed in response to other heavy metals in plants (Sappl et al., 2009

No lethal dose was identified across a wide dose range from 0.006 mg/kg to 20 mg/kg body weight

Body weight considerations Unlike some peptides where dosing scales with body weight, cagrilintide uses fixed doses across weight categories in clinical trials

Supplementary material The Supplementary Material for this article can be found online at: References 1 AngelaI

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