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Injection is much more comfortable if combined with B12 as this dilutes the concentration

When treating migraines, two factors should be taken into account: first, pre-treatment education for patients, which includes avoiding migraine triggers and improving lifestyle choices

Thiamine deficiency reduces the level of synthesis of nucleic acids, fatty acids and steroids, which in turn causes demyelination of nerve fibers

B6 also supports progesterone sensitivity in the brain (helping the brain respond to what progesterone remains)