GH in turn drives the liver to make insulin-like growth factor 1 (IGF-1), which mediates many of GHs downstream effects
2021, Brescoll, Jennifer, and Steven Daveluy
It is the first medication to meaningfully address both sides of the energy balance equation: | Medication | What It Reduces | What It Burns | Max Weight Loss | |-----------|----------------|---------------|-----------------| | Semaglutide | Appetite (GLP-1) | -- | ~15-17% | | Tirzepatide | Appetite (GIP + GLP-1) | Minimal | ~20-22% | | **Retatrutide** | **Appetite (GIP + GLP-1)** | **Calories (Glucagon)** | **~24%** | That additional glucagon column is why retatrutide achieved more weight loss in less time than either competitor
They trade on fame, relatability, and aspirational wellness, not peer-reviewed evidence
Can all three be compared within a single protocol
For Miami patients researching peptide therapy seriously, the right next step is not to commit to whatever was advertised first