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74 The pathophysiology of APAP-induced liver injury involves a complex interplay of cellular events, with inflammasome activation emerging as a critical component of the inflammatory response

Similar content being viewed by others Introduction Redox cycling describes the continuous reduction and oxidation cycle of a compound, forming radical intermediates capable of transferring an electron to molecular oxygen, generating the superoxide radical anion (O 2 . ) 1

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In addition, combining GLP-1R agonists with other peptide agonists or small-molecule therapeutics, including fibroblast growth factor 21 (FGF21), the farnesoid X receptor (FXR) agonist cilofexor with/without the acetyl coenzyme A carboxylase inhibitor firsocostat, a long-acting amylin agonist, cannabinoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors (SGLT-2i), is currently being explored and may lead to additional improvements in NASH features vs GLP-1R agonists therapy alone [79,80,81,82,83]

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