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Another scenario is a patient who has been using a GLP-1 therapy for a few years, has reached a weight-loss plateau, and is now in the maintenance phase of treatment
Brains were cleared using iDISCO standard protocol 62,63
At ATG loci, this erases activating marks such as H3K9ac, H3K14ac, and H4K16ac, thereby limiting ATG expression and autophagy initiation
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