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However, research, like a When there is already a pre-established metabolic disease, it becomes more of an uphill battle to reverse those abnormalities, especially if they have been established for a long time, Glickman says

3.2.3 Anti-inflammatory and anti-fibrotic effects Activation of GLP-1 receptors by dual agonists exerts potent anti-inflammatory effects within the liver microenvironment, which are crucial for preventing progression from steatosis to steatohepatitis and fibrosis

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Studies have shown positive results indicating that GLP-1 or its analog can reduce hepatic gluconeogenesis and lipogenesis, suggesting that GLP-1 can be used in the treatment of NASH 29,30,31

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