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Many people can afford to pay hundreds of dollars a month for a GLP-1 drug, he says, but not most of our patients. Any primary care doctor would hate to see a potent new weapon against chronic disease fall out of reach, but its especially hard for Rind because he knows the data so well

CX3CL1, CX3C ligand 1

Managing nausea doesn't reduce efficacy

If you are truly constipated and cant soften the situation with a change in your diet, drinking more water or getting more physical activity, then, yes, a laxative may do the trick