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Jr, Sinha, D., & Liu, H

This accumulation is mediated by plasmalemmal transporters predominantly expressed in glial cell, such as divalent metal transporter 1 DMT1/SLC11A2 or zinc transporter ZIP14/SLC39A14, 374,375 which both transport Fe 2+ (ferrous), whereas Fe 3+ (ferric) is accumulated through transferrin receptors

PMC 4876946

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Causes of deficiency can include an insufficient diet of animal products, gastrointestinal problems that affect absorption, and certain autoimmune medical conditions

Sun S, Liu S, Duan SZ, Zhang L, Zhou H, Hu Y, et al