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Abstract Osmolytes are naturally occurring small molecular weight organic molecules, which are accumulated in large amounts in all life forms to maintain the stability of cellular proteins and hence preserve their functions during adverse environmental conditions

Long-term complications are off the chart

High ChREBP expression was found in biopsies from NASH patients, but levels declined in patients with severe insulin resistance, indicating that ChREBP may segregate hepatic steatosis from insulin resistance [52]

Through the recognition of self and non-self, immune cells can identify and exhibit responses against pathogenic invaders such as bacteria and viruses (Hemmi et al., 2000