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These may include: Mild pain at the injection site Redness or swelling Headache Nausea Serious reactions are rare, but healthcare professionals must always be prepared to manage them

CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling

Researchers note that intranasal delivery may especially increase the bioavailability of peptide therapeutics and present an appealing alternative to injection [14, 15, 16]